A novel azo-based near-infrared fluorescent theranostic probe was synthesized, which is selectively activated under hypoxic conditions, resulting in the release of an active anticancer drug and a near-infrared fluorophore turn-on. Notably, the probe has been applied successfully to real-time visualization of drug delivery in 4T1, HepG2 cells, and mice.
Keyphrases
- living cells
- fluorescent probe
- quantum dots
- drug delivery
- single molecule
- photodynamic therapy
- papillary thyroid
- sensitive detection
- fluorescence imaging
- locally advanced
- endothelial cells
- type diabetes
- squamous cell
- squamous cell carcinoma
- emergency department
- cancer therapy
- metabolic syndrome
- chemotherapy induced
- drug induced
- rectal cancer