Is ketamine infusion effective and safe as an adjuvant of sedation in the PICU? Results from the Ketamine Infusion Sedation Study (KISS).

Anna Tessari Francesca SperottoFederico PeceGiulia PettenuzzoNicola PorcellatoElisa PolettoMaria Cristina MondardiniAndrea PettenazzoMarco DaverioAngela Amigoni

Published in: Pharmacotherapy (2022)

Ketamine used as a continuous infusion in the PICU might represent a valid strategy to ensure comfort and spare opioids and benzodiazepines in difficult-to-sedate PICU patients. Adverse events are minor and easily reversible. Future study will be needed to investigate long-term outcomes.

Keyphrases

pain management
end stage renal disease
early stage
chronic kidney disease
chronic pain
mechanical ventilation
peritoneal dialysis
prognostic factors
intensive care unit