Nonthyroidal illness syndrome (NTIS) in severe COVID-19 patients: role of T3 on the Na/K pump gene expression and on hydroelectrolytic equilibrium.
Salvatore SciacchitanoCarlo CapalboChristian NapoliAndrea NegroLuciano De BiaseAdriano MarcolongoPaolo AnibaldiValentina SalvatiLea PetrellaLuca MerloDaniela AlampiElisa AlessandriChiara LoffredoAlessandra UlivieriLuca LavraFiorenza MagiAlessandra MorganteLeila B SalehiClaudia De VitisRita ManciniFlaminia ColuzziMonica RoccoPublished in: Journal of translational medicine (2021)
In conclusion, we demonstrated that measurement of BIA parameters is a useful method to analyze water and salt retention in COVID-19 patients hospitalized in ICU and, in particular, in those that develop NTIS. Our results indicate that NTIS has peculiar similarities with myxedema seen in severe hypothyroid patients, albeit it occurs more rapidly. The Na+/K+ pump is a possible target of T3 action, involved in the pathogenesis of the anasarcatic condition observed in our COVID-19 patients with NTIS. Finally, measurement of BIA parameters may represent good endpoints to evaluate the benefit of future clinical interventional trials, based on the administration of T3 in patients with NTIS.
Keyphrases
- sars cov
- gene expression
- end stage renal disease
- coronavirus disease
- ejection fraction
- early onset
- newly diagnosed
- chronic kidney disease
- intensive care unit
- dna methylation
- molecular dynamics
- respiratory syndrome coronavirus
- molecular dynamics simulations
- current status
- drug induced
- extracorporeal membrane oxygenation