Transcriptomic profiling reveals disease-specific characteristics of epithelial cells in idiopathic pulmonary fibrosis.
Maximilian BoeschFlorent BatyMartin H BrutscheMichael TammJulien RouxLars KnudsenAmiq GazdharThomas GeiserPetra KhanKatrin E HostettlerPublished in: Respiratory research (2020)
Our findings support the hypothesis of a functional impairment of IPF-ECs, which could possibly explain the poor clinical outcome of IPF that roughly compares to those of advanced-stage cancers. Our study provides a valuable resource for downstream mechanistic investigation and the quest for novel therapeutic IPF targets.