Natural product derivative Gossypolone inhibits Musashi family of RNA-binding proteins.

Lan LanHao LiuAmber R SmithCarl AppelmanJia YuSarah LarsenRebecca T MarquezXiaoqing WuFrank Y LiuPhilip GaoRagul GowthamanJohn KaranicolasRoberto N De GuzmanSteven RogersJeffrey AubéKristi L NeufeldLiang Xu

Published in: BMC cancer (2018)

Our data suggest that PEGylation improved the bioavailability of Gn as well as achieved tumor-targeted delivery and controlled release of Gn, which enhanced its overall biocompatibility and drug efficacy in vivo. This provides proof of concept for the development of Gn-lip as a molecular therapy for colon cancer with MSI1/MSI2 overexpression.

Keyphrases

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