A systematic review comparing the diagnostic value of 14-3-3 protein in the cerebrospinal fluid, RT-QuIC and RT-QuIC on nasal brushing in sporadic Creutzfeldt-Jakob disease.

Olivia BehaegheElias MangelschotsBart De VilPatrick Cras

Published in: Acta neurologica Belgica (2018)

Nasal brushing, despite being the best diagnostic tool according to the data, needs more study since there has only been a few studies regarding the technique. It is safe to say that due to the high specificity, RT-QuIC is superior to 14-3-3 testing.

Keyphrases

cerebrospinal fluid
chronic rhinosinusitis
late onset
machine learning
amino acid
deep learning
structural basis