ALDOA inhibits cell cycle arrest induced by DNA damage via the ATM-PLK1 pathway in pancreatic cancer cells.

Haidi ChenZeng YeXiaowu XuYi QinChangfeng SongGuixiong FanHaifeng HuYuheng HuXianjun YuWensheng LiuShunrong Ji Wenyan Xu

Published in: Cancer cell international (2021)

Regarding the molecular mechanism, we found that ALDOA inhibited the DDR and improved activation of the cell cycle checkpoint PLK1 by suppressing ATM, which promotes tumour cell progression. Consequently, ALDOA has a profound effect on pancreatic cancer development.

Keyphrases

dna damage
cell cycle
cell cycle arrest
dna repair
cell death
cell proliferation
pi k akt
oxidative stress
single cell
cell therapy
intellectual disability
dna damage response
signaling pathway
stem cells
autism spectrum disorder