Predictive and Prognostic Implications of Circulating CX3CR1 + CD8 + T Cells in Non-Small Cell Lung Cancer Patients Treated with Chemo-Immunotherapy.

Eihab Abdelfatah Mark D Long Ryutaro Kajihara Takaaki Oba Takayoshi Yamauchi Hongbin Chen Joy Sarkar Kristopher M Attwood Junko Matsuzaki Brahm H Segal Grace K Dy Fumito Ito

Published in: Cancer research communications (2023)

Current approaches to combined chemotherapy and anti-PD-1/PD-L1 therapy (chemo-immunotherapy) for patients with NSCLC are limited by the lack of reliable predictive biomarkers. This study shows the utility of T-cell differentiation marker, CX3CR1, as an early on-treatment predictor of response and changes in genomic/transcriptomic signatures of circulating tumor-infiltrating lymphocyte repertoires in patients with NSCLC undergoing chemo-immunotherapy.

Keyphrases

photodynamic therapy
locally advanced
small cell lung cancer
combination therapy
cancer therapy
advanced non small cell lung cancer
squamous cell carcinoma
single cell
peripheral blood
rna seq
stem cells
gene expression
epidermal growth factor receptor
dna methylation
copy number