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Somatic protospacer adjacent motifs are numerous and selectively targetable in cancers.

Selina Shiqing K TehKirsten BowlandAlexis BennettEitan Halper-StrombergAlyza SkaistAparna PallavajjalaJacqueline TangFidel CaiAntonella MacorettaHong LiangSarah WheelanMing-Tseh LinRalph H HrubanRobert B ScharpfNicholas J RobertsJames R Eshleman
Published in: bioRxiv : the preprint server for biology (2023)
We developed a highly efficient somatic PAM discovery approach and found that a large number of somatic PAMs exist in individual tumors. These PAMs could serve as novel targets to selectively kill cancer cells.
Keyphrases
  • highly efficient
  • copy number
  • small molecule
  • high throughput
  • young adults
  • single cell
  • childhood cancer