Somatic protospacer adjacent motifs are numerous and selectively targetable in cancers.

Selina Shiqing K TehKirsten BowlandAlexis BennettEitan Halper-StrombergAlyza SkaistAparna PallavajjalaJacqueline TangFidel CaiAntonella MacorettaHong LiangSarah WheelanMing-Tseh LinRalph H HrubanRobert B ScharpfNicholas J RobertsJames R Eshleman

Published in: bioRxiv : the preprint server for biology (2023)

We developed a highly efficient somatic PAM discovery approach and found that a large number of somatic PAMs exist in individual tumors. These PAMs could serve as novel targets to selectively kill cancer cells.

Keyphrases

highly efficient
copy number
small molecule
high throughput
young adults
single cell
childhood cancer