Somatic protospacer adjacent motifs are numerous and selectively targetable in cancers.
Selina Shiqing K TehKirsten BowlandAlexis BennettEitan Halper-StrombergAlyza SkaistAparna PallavajjalaJacqueline TangFidel CaiAntonella MacorettaHong LiangSarah WheelanMing-Tseh LinRalph H HrubanRobert B ScharpfNicholas J RobertsJames R EshlemanPublished in: bioRxiv : the preprint server for biology (2023)
We developed a highly efficient somatic PAM discovery approach and found that a large number of somatic PAMs exist in individual tumors. These PAMs could serve as novel targets to selectively kill cancer cells.