Angiotensin II Mediates Cardiomyocyte Hypertrophy in Atrial Cardiomyopathy via Epigenetic Transcriptional Regulation.

Liuying ZhengJin WangRui ZhangYingyi ZhangJie GengLu CaoXiaoyun ZhaoJianhui GengXinping DuYue-Cheng Hu Hongliang Cong

Published in: Computational and mathematical methods in medicine (2022)

AngII had a prohypertrophic effect on atrial cardiomyopathy which was epigenetic-dependent. Patients with atrial fibrillation manifest an increased susceptibility to hypertrophy and exhibit epigenetic characteristics that are permissive for the transcription of hypertrophy-related genes. AngII induces histone acetylation via the cytoplasmic-nuclear shuttling of HDACs, which constitutes a novel mechanism of atrial hypertrophy regulation and might provide a promising therapeutic strategy for atrial cardiomyopathy.

Keyphrases

angiotensin ii
dna methylation
atrial fibrillation
left atrial
heart failure
gene expression
catheter ablation
angiotensin converting enzyme
vascular smooth muscle cells
transcription factor
left ventricular
high glucose