Hepatic triglyceride content is intricately associated with numerous metabolites and biochemical pathways.
Tariq O FaquihJan Bert van KlinkenRuifang Li-GaoRaymond NoordamDiana van HeemstSebastiaan BoonePatricia A SheridanGregory MichelottiHildo LambRenée de MutsertFrits R RosendaalAstrid van Hylckama VliegKo Willems van DijkDennis O Mook-KanamoriPublished in: Liver international : official journal of the International Association for the Study of the Liver (2023)
The combined network and pathway analyses indicated extensive associations between BCAA and the lipids pathways with HTGC and the FIB-4 index. Moreover, we report a novel pathway glutamate-metabolonic lactone sulphate-X-15245 with a potential strong association with HTGC. These findings can aid elucidating HTGC metabolomic profiles and provide insight into novel drug targets for fibrosis-related outcomes.