Synthesis of New Fused Heterocyclic 2-Quinolones and 3-Alkanonyl-4-Hydroxy-2-Quinolones.

Ashraf A AlyAlaa A HassanNasr K MohamedLamiaa E Abd El-HaleemStefan BräseMika PolamoMartin NiegerAlan B Brown

Published in: Molecules (Basel, Switzerland) (2019)

Herein, we report the synthesis of 5,12-dihydropyrazino[2,3-c:5,6-c']difuro[2,3-c:4,5-c']-diquinoline-6,14(5H,12H)diones, 2-(4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl)-1,4-diphenyl- butane-1,4-diones and 4-(benzo-[d]oxazol-2-yl)-3-hydroxy-1H-[4,5]oxazolo[3,2-a]pyridine-1-one. The new candidates were synthesized and identified by different spectroscopic techniques, and X-ray crystallography.

Keyphrases

molecular docking
high resolution
magnetic resonance imaging
computed tomography
molecular dynamics simulations