BK Ca nitrosylation is associated with cerebral microvascular dysfunction in female 5x-FAD mice.

Josiane Fernandes SilvaFelipe D PolkAndrea SavuAllison M KathMichael T GeePaulo Wagner Pires

Published in: bioRxiv : the preprint server for biology (2023)

S-nitrosylation linked to reduced activity and, consequently, higher basal myogenic tone. These changes were associated with lower perfusion of the frontal cortex and impaired neurovascular reactivity, suggesting that nitro-oxidative stress is an important mechanism of vascular dysfunction in Alzheimer's disease.

Keyphrases

oxidative stress
functional connectivity
dna damage
ischemia reperfusion injury
skeletal muscle
induced apoptosis
cognitive decline
high fat diet induced
working memory
subarachnoid hemorrhage
diabetic rats
magnetic resonance imaging
contrast enhanced
signaling pathway
endoplasmic reticulum stress
heat stress