Epilepsy Phenotype and Its Reproducibility After Lateral Fluid-Percussion -Induced Traumatic Brain Injury In Rats - A Multicenter EpiBioS4Rx Study Project 1.
Xavier Ekolle Ndode-EkaneIdrish AliCesar E Santana-GomezPedro AndradeRiikka ImmonenPablo Miguel Casillas-EspinosaTomi PaananenEppu ManninenNoora PuhakkaGregory SmithRhys D BradyJuliana C SilvaEmma BraineMatt HudsonGlen R YamakawaNigel Charles JonesSandy R ShultzNeil G HarrisDavid K WrightOlli GröhnRichard StabaTerence J O'BrienAsla PitkänenPublished in: Epilepsia (2023)
The PTE phenotype induced by lateral FPI is reproducible in a multi-center design. Our study supports the feasibility of performing pre-clinical multicenter trials in PTE to increase statistical power and experimental rigor to produce clinically translatable data to combat epileptogenesis after TBI.