Clustered Mendelian randomization analyses identify distinct and opposing pathways in the association between genetically influenced insulin-like growth factor-1 and type 2 diabetes mellitus.

Wenyi WangEphrem Baraki TesfayJan Bert van KlinkenKo Willems van DijkAndrzej BartkeDiana van HeemstRaymond Noordam

Published in: International journal of epidemiology (2022)

The IGF-1-associated SNPs used as genetic instruments in MR analyses showed a heterogeneous distribution of MR effect estimates on the risk of type 2 diabetes. This was likely explained by differences in the underlying molecular pathways that increase IGF-1 concentration and differentially mediate the effects of IGF-1 on type 2 diabetes.

Keyphrases

growth hormone
type diabetes
pi k akt
glycemic control
binding protein
genome wide
contrast enhanced
magnetic resonance
cardiovascular disease
signaling pathway
insulin resistance
magnetic resonance imaging
dna methylation
copy number
metabolic syndrome
gene expression
skeletal muscle
genome wide association