Relationship between Semi-Quantitative Parameters of Thallium-201 Myocardial Perfusion Imaging and Coronary Artery Disease.
Chin-Chuan ChangMing-Hui YangChih-Ting LiuHsiu-Lan ChuChia-Yang LinWei-Jheng YenChao-Yu ChungSheng-Yow HoYu-Chang TyanPublished in: Diagnostics (Basel, Switzerland) (2020)
This study aimed to investigate the diagnostic performance of semi-quantitative parameters of thallium-201 myocardial perfusion imaging (MPI) for coronary artery disease (CAD). From January to December 2017, patients were enrolled who had undergone Tl-201 MPI and received cardiac catheterization for coronary artery disease within three months of MPI. Receiver operating characteristics (ROC) analysis was used to determine the optimal cutoff values of semi-quantitative parameters. A comparison of the sensitivity and specificity of these parameters based on different subgroupings was further performed. A total of 130 patients were enrolled for further analysis. Among the collected parameters, the stress total perfusion deficit (sTPD) had the highest value of the area under curve (0.813) under the optimal cutoff value of 3.5%, with a sensitivity and specificity of 73.5% and 74.5%, respectively (p = 0.0000), for the diagnosis of CAD. With further subgrouping analysis based on history of diabetes or dyslipidemia, the sensitivity and specificity showed similar results. Based on the currently collected data and image acquisition conditions, the sTPD parameter has a clinical role for the diagnosis of CAD with a cutoff value of 3.5%.
Keyphrases
- coronary artery disease
- high resolution
- end stage renal disease
- percutaneous coronary intervention
- ejection fraction
- newly diagnosed
- peritoneal dialysis
- chronic kidney disease
- coronary artery bypass grafting
- type diabetes
- cardiovascular disease
- prognostic factors
- left ventricular
- adipose tissue
- metabolic syndrome
- computed tomography
- magnetic resonance imaging
- patient reported
- insulin resistance
- artificial intelligence
- aortic valve
- magnetic resonance