Polypharmacy and the risk of drug-drug interactions and potentially inappropriate medications in hospital psychiatry.
Jan WolffGudrun HefnerClaus NormannKlaus KaierHarald BinderChristoph HiemkeSermin TotoKatharina DomschkeMichael MarschollekAnsgar KlimkePublished in: Pharmacoepidemiology and drug safety (2021)
Polypharmacy is frequent in clinical care. The number of used drugs is a proven risk factor of adverse drug reactions due to drug-drug interactions and potentially inappropriate medication use in the elderly. The potential interactions and the specific pharmacokinetics and -dynamics of older patients should always be considered when multiple drugs are used.