The caveolar membrane system in endothelium: From cell signaling to vascular pathology.
Antonio FilippiniGigliola SicaAlessio D'AlessioPublished in: Journal of cellular biochemistry (2018)
Caveolae are 50- to 100-nm cholesterol and glycosphingolipid-rich flask-shaped invaginations commonly observed in many terminally differentiated cells. These organelles have been described in many cell types and are particularly abundant in endothelial cells, where they have been involved in the regulation of certain signaling pathways. Specific scaffolding proteins termed caveolins, along with the more recently discovered members of the cavin family, represent the major protein components during caveolae biogenesis. In addition, multiple studies aimed to investigate the expression and the regulation of these proteins significantly contributed to elucidate the role of caveolae and caveolins in endothelial cell physiology and disease. The aim of this review is to survey recent evidence of the involvement of the caveolar network in endothelial cell biology and endothelial cell dysfunction.
Keyphrases
- endothelial cells
- high glucose
- single cell
- induced apoptosis
- vascular endothelial growth factor
- cell therapy
- signaling pathway
- oxidative stress
- nitric oxide
- binding protein
- photodynamic therapy
- cell proliferation
- small molecule
- epithelial mesenchymal transition
- low density lipoprotein
- protein protein
- amino acid
- network analysis