SARS-CoV-2 binds platelet ACE2 to enhance thrombosis in COVID-19.

Si ZhangYangyang LiuXiaofang WangLi YangHaishan LiYuyan WangMengduan LiuXiaoyan ZhaoYouhua XieYan YangShenghui ZhangZhichao FanJianzeng DongZhenghong YuanZhongren DingYi ZhangLiang Hu

Published in: Journal of hematology & oncology (2020)

Our findings uncovered a novel function of SARS-CoV-2 on platelet activation via binding of Spike to ACE2. SARS-CoV-2-induced platelet activation may participate in thrombus formation and inflammatory responses in COVID-19 patients.

Keyphrases

sars cov
respiratory syndrome coronavirus
angiotensin converting enzyme
angiotensin ii
high glucose
diabetic rats
coronavirus disease
oxidative stress