UBE2T promotes autophagy via the p53/AMPK/mTOR signaling pathway in lung adenocarcinoma.

Jin-Hong ZhuHaijiao AoMingdong LiuKui CaoJianqun Ma

Published in: Journal of translational medicine (2021)

We found that UBE2T upregulates autophagy in NSCLC cells by activating the p53/AMPK/mTOR signaling pathway. The clinical predicting ability of UBE2T in LUAD can be improved by considering the autophagy-regulatory role of UBE2T.

Keyphrases

signaling pathway
induced apoptosis
pi k akt
endoplasmic reticulum stress
cell cycle arrest
epithelial mesenchymal transition
cell death
cell proliferation
small cell lung cancer
oxidative stress
skeletal muscle
protein kinase
advanced non small cell lung cancer
tyrosine kinase