Validation of a Diet-Induced Macaca fascicularis Model of Nonalcoholic Steatohepatitis with Dietary and Pioglitazone Interventions.

Raul C Camacho David C PolidoriTao ChenBin ChenHelen Han HsuBin GaoMathieu MarellaMariusz LubomirskiTraymon BeaversJavier CabreraPeggy WongAndrea R Nawrocki

Published in: Diabetes, obesity & metabolism (2022)

Both weight loss induced by DSCR and treatment with pioglitazone improve histological features of NASH in a diet-induced cynomolgus monkey model. This model provides a translational preclinical model for testing novel NASH therapies. This article is protected by copyright. All rights reserved.

Keyphrases

weight loss
physical activity
bariatric surgery
type diabetes
body mass index
bone marrow