X chromosome aneuploidies and schizophrenia: association analysis and phenotypic characterization.

Itaru KushimaBranko AleksicHiroki KimuraMasahiro NakatochiTzuyao Lo Kyung Sue HongMakoto AraiRyota HashimotoShusuke NumataYasunobu OkamuraTaku ObaraToshiya Inada Norio Ozaki

Published in: Psychiatry and clinical neurosciences (2022)

These findings indicate that both 47, XXY and 47, XXX are significantly associated with risk for SCZ. Patients with SCZ with 47, XXY may be characterized by treatment-resistance and manic symptoms.

Keyphrases

bipolar disorder
copy number
gene expression
sleep quality
physical activity
depressive symptoms