Inhibition of integrated stress response protects against lipid-induced senescence in hypothalamic neural stem cells in adamantinomatous craniopharyngioma.

Chaohu WangHuarong ZhangJun FanQing LiRongrong GuoJun PanYawei LiuJunxiang PengQianchao ZhuYiwen FengChengdong WuPeng LuoXiaoyu QiuJin ShiYingying DengSong-Tao QiYi Liu

Published in: Neuro-oncology (2022)

Reduced LD aggregation or ISR signaling inhibition prevented senescence in htNSCs and identified molecular pathways and potential therapeutic targets that may improve hypothalamic dysfunction in ACP patients.

Keyphrases

neural stem cells
end stage renal disease
dna damage
ejection fraction
endothelial cells
prognostic factors
risk assessment
patient reported outcomes
climate change