Neonatal hyperglycemia induces CXCL10/CXCR3 signaling and microglial activation and impairs long-term synaptogenesis in the hippocampus and alters behavior in rats.
Katherine M SatromKathleen EnnisBrian M SweisTatyana M MatveevaJun ChenLeif HansonAkhil MaheshwariRaghavendra RaoPublished in: Journal of neuroinflammation (2018)
Neonatal hyperglycemia induces CXCL10/CXCR3 signaling, microglial activation, and astrocytosis in the rat hippocampus and alters long-term synaptogenesis and behavior. These results may explain the hippocampus-specific cognitive deficits common in ELGAN who experience neonatal hyperglycemia.