Does histological assessment accurately distinguish separate primary lung adenocarcinomas from intrapulmonary metastases? A study of paired resected lung nodules in 32 patients using a routine next-generation sequencing panel for driver mutations.
Frido K BruehlErika E DoxtaderYu-Wei ChengDaniel H FarkasCarol FarverSanjay MukhopadhyayPublished in: Journal of clinical pathology (2021)
A small but significant subset of two-nodule adenocarcinoma pairs is inaccurately judged as related by histological assessment, and can be proven to be unrelated by molecular analysis (driver gene mutations), leading to significant downstaging.