Selective intracellular delivery of perfluorocarbon nanodroplets for cytotoxicity threshold reduction on ultrasound-induced vaporization.
Ayumu IshijimaSatoshi YamaguchiTakashi AzumaEtsuko KobayashiYoshikazu ShibasakiTeruyuki NagamuneIchiro SakumaPublished in: Cancer reports (Hoboken, N.J.) (2019)
Intracellular delivery of PCNDs reduced ultrasound pressure applied for vaporization to induce cytotoxicity. Confocal laser scanning microscopy and flow cytometry revealed that prolonged PCND-cell incubation increased PCND uptake and aggregation. This aggregation effect might have contributed to the cytotoxicity threshold reduction effect.