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Selective intracellular delivery of perfluorocarbon nanodroplets for cytotoxicity threshold reduction on ultrasound-induced vaporization.

Ayumu IshijimaSatoshi YamaguchiTakashi AzumaEtsuko KobayashiYoshikazu ShibasakiTeruyuki NagamuneIchiro Sakuma
Published in: Cancer reports (Hoboken, N.J.) (2019)
Intracellular delivery of PCNDs reduced ultrasound pressure applied for vaporization to induce cytotoxicity. Confocal laser scanning microscopy and flow cytometry revealed that prolonged PCND-cell incubation increased PCND uptake and aggregation. This aggregation effect might have contributed to the cytotoxicity threshold reduction effect.
Keyphrases
  • flow cytometry
  • magnetic resonance imaging
  • single cell
  • high resolution
  • optical coherence tomography
  • high speed
  • reactive oxygen species
  • ultrasound guided
  • high glucose
  • oxidative stress
  • computed tomography