Proteomic signatures of schizophrenia-sourced iPSC-derived neural cells and brain organoids are similar to patients' postmortem brains.
Juliana Minardi NascimentoVerônica M Saia-CeredaGiuliana S ZuccoliGuilherme Reis-de-OliveiraVictor Corasolla CarregariBradley J SmithStevens Kastrup RehenDaniel Martins-de-SouzaPublished in: Cell & bioscience (2022)
In conclusion, here we provide comprehensive, large-scale, protein-level data of different neural cell models that may uncover early events in brain development, underlying several of the mechanisms within the origins of schizophrenia.
Keyphrases
- bipolar disorder
- end stage renal disease
- resting state
- white matter
- ejection fraction
- chronic kidney disease
- induced apoptosis
- prognostic factors
- peritoneal dialysis
- single cell
- functional connectivity
- stem cells
- genome wide
- multiple sclerosis
- oxidative stress
- cell cycle arrest
- patient reported outcomes
- signaling pathway
- dna methylation
- machine learning
- cell proliferation
- bone marrow
- endoplasmic reticulum stress
- artificial intelligence
- amino acid