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Mesothelin CAR T-cells secreting anti-FAP/anti-CD3 molecules efficiently target pancreatic adenocarcinoma and its stroma.

Marc WehrliSamantha GuinnFilippo BirocchiAdam KuoYi SunRebecca C LarsonAntonio J AlmazanIrene ScarfoAmanda A BouffardStefanie R BaileyPraju Vikas AnekalPaula Montero LlopisLinda T NiemanYuhui SongKatherine H XuTrisha R BergerMichael C KannMark B LeickHarrison SilvaDiego Salas-BenitoTamina KienkaKorneel GrauwetTodd D ArmstrongRui ZhangQingfeng ZhuJuan FuAndrea SchmidtsFelix KorellMax JanBryan D ChoiAndrew S LissGenevieve Marie BolandDavid Tsai TingRichard Andrew BurkhartRussell William JenkinsLei ZhengElizabeth D ThompsonJacquelyn W ZimmermanMarcela V Maus
Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)
CAR-TEAM cells enable modification of tumor stroma, leading to increased elimination of PDAC tumors. This approach represents a promising treatment option for pancreatic cancer.
Keyphrases
  • induced apoptosis
  • cell cycle arrest
  • palliative care
  • endoplasmic reticulum stress
  • signaling pathway
  • cell death
  • combination therapy
  • nk cells
  • smoking cessation