Association of common genetic variants related to atrial fibrillation and the risk of ventricular fibrillation in the setting of first ST-elevation myocardial infarction.

Reza JabbariJavad JabbariCharlotte GlingeBjarke RisgaardStefan SattlerBo Gregers WinkelChristian Juhl TerkelsenHans-Henrik TilstedLisette Okkels JensenMikkel HougaardStig HaunsøThomas EngstrømChristine M AlbertJacob Tfelt-Hansen

Published in: BMC medical genetics (2017)

In this study, we found that the 24 AF-associated SNPs may not be involved in increasing the risk of VF. Larger VF cohorts and use of new next generation sequencing and epigenetic may in future identify additional AF and VF risk loci and improve our understanding of genetic pathways behind the two arrhythmias.

Keyphrases

atrial fibrillation
st elevation myocardial infarction
percutaneous coronary intervention
genome wide
catheter ablation
dna methylation
heart failure
left atrial
copy number
oral anticoagulants
left atrial appendage
gene expression
direct oral anticoagulants
acute coronary syndrome
genome wide association