Inflammation-induced cholestasis in cancer cachexia.
Morgane M ThibautMartina SboarinaMartin RoumainSarah A PötgensAudrey M NeyrinckFlorence DestréeJustine GillardIsabelle A LeclercqGuillaume DachyJean-Baptiste DemoulinAnne TailleuxSophie LestavelMarialetizia RastelliAmandine EverardPatrice D CaniPaolo Ettore PorporatoAudrey LoumayeJean-Paul ThissenGiulio G MuccioliNathalie M DelzenneLaure B BindelsPublished in: Journal of cachexia, sarcopenia and muscle (2020)
We show alterations in bile acid metabolism and hepatobiliary secretion in cancer cachexia. In this context, we demonstrate the contribution of systemic inflammation to the impairment of the hepatobiliary transport system and the role played by bile acids in the hepatic inflammation. This work paves the way to a better understanding of the role of the liver in cancer cachexia.