P53 Regulates the Extent of Fibroblast Proliferation and Fibrosis in Left Ventricle Pressure Overload.
Xiaoyi LiuRyan M BurkeJanet K LighthouseCameron D BakerRonald A DirkxBrian KangYashoswini ChakrabortyDeanne M MickelsenJennifer TwardowskiStephano S MelloJohn M AshtonEric M SmallPublished in: Circulation research (2023)
This study reveals a mechanism regulating cardiac fibroblast accumulation and ECM secretion, orchestrated in part by p53-dependent cell cycle control that governs the timing and extent of fibrosis in left ventricular pressure overload.