Hepcidin-regulating iron metabolism genes and pancreatic ductal adenocarcinoma: a pathway analysis of genome-wide association studies.
Sachelly Julián-SerranoFangcheng YuanWilliam WheelerBeben BenyaminMitchell J MachielaAlan A ArslanLaura E Beane-FreemanPaige M BracciEric J DuellMengmeng DuSteven GallingerGraham G GilesPhyllis J GoodmanCharles KooperbergLoic Le MarchandRachel E NealeXiao-Ou ShuStephen K Van den EedenKala VisvanathanWei ZhengDemetrios AlbanesGabriella AndreottiEva ArdanazAna BabicSonja I BerndtLauren K BraisPaul BrennanBas Bueno-de-MesquitaJulie E BuringStephen J ChanockErica J ChildsCharles C ChungEleonora FabiánováLenka ForetováCharles S FuchsJ Michael GazianoManuel GentiluomoEdward L GiovannucciMichael G GogginsThilo HackertPatricia HartgeManal M HassanIvana HolcátováElizabeth A HollyRayjean I HungVladimir JanoutRobert C KurtzI-Min LeeNúria MalatsDavid McKeanRoger L MilneChristina C NewtonAnn L ObergSandra PerdomoUlrike PetersMiquel PortaNathaniel RothmanMatthias B SchulzeHoward D SessoDebra T SilvermanIan M ThompsonJean Wactawski-WendeElisabete WeiderpassNicolas WenstzensenEmily WhiteLynne R WilkensHerbert YuAnne Zeleniuch-JacquotteJun ZhongPeter KraftDounghui LiPeter T CampbellGloria M PetersenBrian M WolpinHarvey A RischLaufey T AmundadottirAlison P KleinKai YuRachael Z Stolzenberg-SolomonPublished in: The American journal of clinical nutrition (2021)
Our results support that genetic susceptibility related to the hepcidin-regulating gene pathway is associated with PDAC risk and suggest a potential role of iron metabolism in pancreatic carcinogenesis. Further studies are needed to evaluate effect modification by intake of iron-rich foods on this association.