In rheumatoid arthritis patients, total IgA1 and IgA2 levels are elevated: Implications for the mucosal origin hypothesis.
Veerle F A M DerksenCornelia F AllaartAnnette H M Van der Helm-Van MilTom W J HuizingaRené E M ToesDiane van der WoudePublished in: Rheumatology (Oxford, England) (2022)
RA patients have raised IgA1 and IgA2 levels. No shift towards IgA2 was observed, indicating that the increase in total IgA is not due to translocation of mucosal IgA into the bloodstream. However, mucosal inflammation might play are role, given the association between smoking and total IgA2 levels. Despite its pro-inflammatory properties, IgA2 does not associate strongly with pro-inflammatory markers in RA patients.