Predictors of Chemosensitivity in Triple Negative Breast Cancer: An Integrated Genomic Analysis.

Tingting JiangWeiwei ShiVikram B WaliLőrinc S PongorCharles LiRosanna LauBalázs GyőrffyRichard P LiftonWilliam F SymmansLajos PusztaiChristos Hatzis

Published in: PLoS medicine (2016)

The comprehensive molecular analysis presented in this study directly links BRCA deficiency with increased clonal mutation burden and significantly enhanced chemosensitivity in TNBC and suggests that functional RNA-based BRCA deficiency needs to be further examined in TNBC.

Keyphrases

replacement therapy
risk factors
nucleic acid
smoking cessation