Copy number variant hotspots in Han Taiwanese population induced pluripotent stem cell lines - lessons from establishing the Taiwan human disease iPSC Consortium Bank.
Ching-Ying HuangLing-Hui LiWan-Tseng HsuYu-Che ChengMartin W NicholsonChun-Lin LiuChien-Yu TingHui-Wen KoShih-Han SyuCheng-Hao WenZhuge YanHsiang-Po HuangHong-Lin SuPo-Min ChiangChia-Ning ShenHsin-Fu ChenB Lin Ju YenHuai-En LuShiaw-Min HwangShih-Hwa ChiouHong-Nerng HoJer-Yuarn WuTimothy J KampJoseph C WuPatrick Ching-Ho HsiehPublished in: Journal of biomedical science (2020)
The CNV hotspots induced by cell reprogramming have successfully been identified in the current study. This finding may be used as a reference index for evaluating iPSC quality for future clinical applications. Our aim was to establish a national iPSC resource center generating iPSCs, made available to researchers, to benefit the stem cell community in Taiwan and throughout the world.