The role of the gut microbiome in cancer-related fatigue: pilot study on epigenetic mechanisms.

Canhua XiaoVeronika FedirkoJonathan BeitlerJinbing BaiGang PengChao ZhouJianlei GuHongyu ZhaoI-Hsin LinCynthia E ChicoSangchoon JeonTish M KnobfKaren N ConneelyKristin HigginsDong M ShinNabil SabaAndrew MillerDeborah Bruner

Published in: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer (2020)

Our results suggest different patterns of the gut microbiota in cancer patients with high vs. low fatigue. Results from functional pathways and DNA methylation analyses indicate that inflammation is likely to be the major driver in the gut-brain axis for cancer-related fatigue.

Keyphrases

dna methylation
sleep quality
gene expression
oxidative stress
genome wide
resting state
multiple sclerosis
functional connectivity
blood brain barrier
copy number