Hypersonins A-D, Polycyclic Polyprenylated Acylphloroglucinols with a 1,2-seco-Homoadamantane Architecture from Hypericum wilsonii.
Shuangshuang XieXiaosheng TanYaping LiuYulin DuanGang ChenHao FengLingjuan SunYingying HuangYi GuoZhengyi ShiYuan ZhouChangxing QiYong-Hui ZhangPublished in: Journal of natural products (2020)
Hypersonins A-D (1-4), four 1,2-seco-homoadamantane type polycyclic polyprenylated acylphloroglucinols (PPAPs) possessing a new bicyclo[4.3.1]decane-3-methoxycarbonyl architecture, were obtained from Hypericum wilsonii. The structures of hypersonins A-D were identified by spectroscopic data, electronic circular dichroism comparison, and X-ray crystallographic data. Hypersonins A-D are the first seco-homoadamantane-type PPAPs with cleavage at the C-1-C-2 bond. Hypersonin A (1) showed moderate inhibitory activity to anti-CD3/anti-CD28 monoclonal antibody-induced proliferation of murine splenocytes, with an IC50 value of 8.3 ± 0.2 μM.
Keyphrases
- monoclonal antibody
- electronic health record
- high resolution
- big data
- molecular docking
- signaling pathway
- diabetic rats
- high glucose
- high intensity
- nk cells
- oxidative stress
- magnetic resonance
- transcription factor
- mass spectrometry
- computed tomography
- stress induced
- molecular dynamics simulations
- electron microscopy