Decreased Cortical Thickness in the Anterior Cingulate Cortex in Adults with Autism.
Charles LaidiJennifer BoisgontierAmicie de PierrefeuEdouard DuchesnaySevan HotierMarc-Antoine d'AlbisRichard DelormeFederico BolognaniChristian CzechCéline BouquetAnouck AmestoyJulie PetitŠtefan HoligaJuergen DukartAlexandru GamanElie ToledanoMyriam Ly-Le MoalIsabelle ScheidMarion LeboyerJosselin HouenouPublished in: Journal of autism and developmental disorders (2019)
Autism spectrum disorder (ASD) is a developmental disorder underdiagnosed in adults. To date, no consistent evidence of alterations in brain structure has been reported in adults with ASD and few studies were conducted at that age. We analyzed structural magnetic resonance imaging data from 167 high functioning adults with ASD and 195 controls. We ran our analyses on a discovery (n = 301) and a replication sample (n = 61). The right caudal anterior cingulate cortical thickness was significantly thinner in adults with ASD compared to controls in both the discovery and the replication sample. Our work underlines the relevance of studying the brain anatomy of an adult ASD population.
Keyphrases
- autism spectrum disorder
- intellectual disability
- attention deficit hyperactivity disorder
- functional connectivity
- resting state
- magnetic resonance imaging
- small molecule
- white matter
- high throughput
- optical coherence tomography
- computed tomography
- cerebral ischemia
- multiple sclerosis
- working memory
- case control
- artificial intelligence
- deep learning
- data analysis
- contrast enhanced