Stimulating effect of palmitate and insulin on cell migration and proliferation in PNT1A and PC3 prostate cells: Counteracting role of metformin.
Breno C LandimMariana M de JesusBeatriz P BosqueRenata G ZanonClaudio V da SilvaRejane Maira GóesDaniele Lisboa RibeiroPublished in: The Prostate (2018)
Higher concentrations of palmitate on PC3 cells and palmitate and insulin on PNT1A cells stimulate cellular activities that could favor cancer progression. Metformin inhibited most of these stimuli, showing the efficacy of this drug for cancer adjuvant therapy in obese patients (a group at increased risk for the development of prostrate cancer).
Keyphrases
- papillary thyroid
- obese patients
- induced apoptosis
- cell migration
- type diabetes
- squamous cell
- prostate cancer
- bariatric surgery
- cell cycle arrest
- emergency department
- lymph node metastasis
- endoplasmic reticulum stress
- roux en y gastric bypass
- metabolic syndrome
- adipose tissue
- weight loss
- insulin resistance
- skeletal muscle
- adverse drug