Pulvinar neuromodulation for seizure monitoring and network modulation in temporal plus epilepsy.
Yash Shashank VakilnaGanne ChaitanyaMuhammad Ubaid HafeezAdeel IlyasManojkumar SaranathanJay GavvalaNitin TandonSandipan PatiPublished in: Annals of clinical and translational neurology (2023)
Deep brain stimulation (DBS) is a promising treatment for drug-refractory epilepsies (DRE) when targeting the anterior nuclei of thalamus (ANT). However, targeting other thalamic nuclei, such as the pulvinar, shows therapeutic promise. Our pioneering case study presents the application of ambulatory seizure monitoring using spectral fingerprinting (12.15-17.15 Hz) recorded through Medtronic Percept DBS implanted bilaterally in the medial pulvinar thalami. This technology offers unprecedented opportunities for real-time monitoring of seizure burden and thalamocortical network modulation for effective seizure reduction in patients with bilateral mesial temporal and temporal plus epilepsies that are not suitable for resection.
Keyphrases
- deep brain stimulation
- temporal lobe epilepsy
- parkinson disease
- obsessive compulsive disorder
- cancer therapy
- blood pressure
- optical coherence tomography
- risk factors
- case report
- emergency department
- combination therapy
- adverse drug
- machine learning
- network analysis
- magnetic resonance imaging
- electronic health record