Mental Health and Autosomal Dominant Polycystic Kidney Disease: A Narrative Review.
Niloufar EbrahimiPranav S GarimellaFouad T ChebibMatthew A SparksEdgar V LermaMohadese GolsorkhiZohreh Gholizadeh GhozloujehAmir AbdipourSayna NorouziPublished in: Kidney360 (2024)
Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disorder marked by the development of cysts in the kidneys and other organs, leading to diverse clinical manifestations, including kidney failure. The psychological burden of ADPKD is substantial, with significant contributors including pain, daily life disruptions, depression, anxiety, and the guilt associated with transmitting ADPKD to offspring. This review details the psychological impacts of ADPKD on patients, addressing how they navigate physical and emotional challenges, including pain management, genetic guilt, mood disorders, and disease acceptance. This review also underscores the need for comprehensive research into the psychological aspects of ADPKD, focusing on the prevalence and contributing factors of emotional distress and identifying effective strategies for managing anxiety and depression. Furthermore, it highlights the importance of understanding the diverse factors that influence patients' quality of life and advocates for holistic interventions to address these psychological challenges.
Keyphrases
- polycystic kidney disease
- pain management
- mental health
- end stage renal disease
- sleep quality
- newly diagnosed
- ejection fraction
- chronic pain
- physical activity
- prognostic factors
- peritoneal dialysis
- risk factors
- depressive symptoms
- metabolic syndrome
- genome wide
- high fat diet
- neuropathic pain
- dna methylation
- skeletal muscle