Integrated analysis reveals prognostic value of HLA-I LOH in triple-negative breast cancer.

Yi-Fan ZhouYi XiaoXi JinGen-Hong DiYi-Zhou JiangZhi-Ming Shao

Published in: Journal for immunotherapy of cancer (2022)

Our study illustrates the genomic landscape of HLA-I functional status and stresses the prognostic significance of HLA-I LOH in TNBCs. For "cold" tumors in TNBCs, HLA-I LOH indicated a worse prognosis than HLA-I non-LOH.

Keyphrases

gene expression
single cell
genome wide