Esc-1GN shows therapeutic potentials for acne vulgaris and inflammatory pain.
Tiaofei YeJiena WuZhengnan XuJinwei ChaiQingye ZengBaishuang ZengYahua GaoRuiyin GuoXin ChenXue-Qing XuPublished in: Journal of peptide science : an official publication of the European Peptide Society (2020)
The inflammatory response plays important roles in acne vulgaris and pain pathogenesis. In previous study, Esc-1GN with anti-inflammatory, antimicrobial, and lipopolysacchride (LPS) binding activity was identified from the skin of the frog Hylarana guentheri. Here, we report its therapeutic potentials for acne vulgaris and inflammatory pain. Esc-1GN destroyed the cell membrane of Propionibacteria acnes in the membrane permeability assays. In addition, bacterial agglutination test suggested that Esc-1GN triggered the agglutination of P. acnes, which was affected by LPS and Ca2+ . Meanwhile, in vivo anti-P. acnes and anti-inflammatory effects of Esc-1GN were confirmed by reducing the counts of P. acnes in mice ear, relieving P. acnes-induced mice ear swelling, decreasing mRNA expression and the production of pro-inflammatory cytokines, and attenuating the infiltration of inflammatory cells. Moreover, Esc-1GN also displayed antinociceptive effect in mice induced by acetic acid and formalin. Therefore, Esc-1GN is a promising candidate drug for treatment of acne vulgaris and inflammatory pain.
Keyphrases
- anti inflammatory
- chronic pain
- inflammatory response
- pain management
- neuropathic pain
- oxidative stress
- high fat diet induced
- hidradenitis suppurativa
- induced apoptosis
- lipopolysaccharide induced
- type diabetes
- lps induced
- spinal cord
- high throughput
- postoperative pain
- toll like receptor
- endothelial cells
- drug induced
- high glucose
- adipose tissue
- skeletal muscle
- dna binding