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Phosphine-Catalyzed Cascade Michael Addition/[4+2] Cycloaddition Reaction of Allenoates and 2-Arylidene-1,3-indanediones.

Wangyu ShiBiming MaoJiaqing XuQijun WangWei WangYongjun WuXuefeng LiHongchao Guo
Published in: Organic letters (2020)
The phosphine-catalyzed cascade Michael addition/[4+2] cycloaddition reaction of tetrahydrobenzofuranone-derived allenoates and 2-arylidene-1,3-indanediones has been reported, affording spirocyclic 1,3-indanedione derivatives in moderate to high yields with moderate to good diastereoselectivities. A scaled-up reaction worked well under mild conditions, and a plausible mechanism is proposed.
Keyphrases
  • room temperature
  • high intensity
  • electron transfer