SARS-CoV-2 detection in primary thyroid sarcoma: coincidence or interaction?

Maria Laura TandaS IppolitoD GalloA BajF NovazziA GenoniM AnnoniN ManciniN ClementiG FinziE PiantanidaP PremoliA LaiD Dalla GasperinaF MaggiS Uccella

Published in: Journal of endocrinological investigation (2022)

In our hypothesis, SARS-CoV-2 and sarcoma coexistence could represent a synergistic interplay, ultimately favoring both viral persistence and tumor proliferation: the overexpression of MDM2 in tumor cells might have generated a favorable immunological niche for SARS-CoV-2 localization and, in turn, SARS-CoV-2 could have favored tumor growth by inducing MDM2-mediated p53 downregulation. Functional studies are needed to confirm this suggestive pathway.

Keyphrases

sars cov
respiratory syndrome coronavirus
cell proliferation
signaling pathway
transcription factor
drug delivery
cancer therapy
label free
single molecule