Neurogenetic mechanisms of risk for ADHD: Examining associations of polygenic scores and brain volumes in a population cohort.

Quanfa HeTaylor J KedingQi ZhangJiacheng MiaoJustin D RussellRyan J HerringaQiongshi LuBrittany G TraversJames J Li

Published in: Journal of neurodevelopmental disorders (2023)

The AnnoPred ADHD PGS was a more developmentally specific predictor of adolescent IA symptoms compared to the traditional ADHD PGS. However, brain volumes did not mediate the effects of either a traditional or AnnoPred ADHD PGS on ADHD symptoms, suggesting that we may still be underpowered in clarifying brain-based biomarkers for ADHD using genetic measures.

Keyphrases

attention deficit hyperactivity disorder
autism spectrum disorder
working memory
resting state

white matter
mental health
young adults
functional connectivity

cerebral ischemia
gene expression
multiple sclerosis

dna methylation
genome wide
sleep quality