Neurogenetic mechanisms of risk for ADHD: Examining associations of polygenic scores and brain volumes in a population cohort.

Quanfa HeTaylor J KedingQi ZhangJiacheng MiaoJustin D RussellRyan J HerringaQiongshi LuBrittany G TraversJames J Li
Published in: Journal of neurodevelopmental disorders (2023)
The AnnoPred ADHD PGS was a more developmentally specific predictor of adolescent IA symptoms compared to the traditional ADHD PGS. However, brain volumes did not mediate the effects of either a traditional or AnnoPred ADHD PGS on ADHD symptoms, suggesting that we may still be underpowered in clarifying brain-based biomarkers for ADHD using genetic measures.