Novel metabolic biomarkers for the diagnosis of acute ischemic stroke.

Aim: To identify novel metabolic biomarkers for patients with acute ischemic stroke (AIS). Methods: The metabolites in the sera of 63 patients with AIS aged 45∼77 years and 60 healthy individuals were analyzed by liquid chromatography (LC)-mass spectrometry (MS)/MS. The efficiency of significantly altered metabolites as biomarkers of AIS was evaluated by ROC curve analysis. Results: Different metabolic profiles were revealed in AIS patients' sera compared with healthy persons. Twelve significantly altered metabolites had an area under the curve (AUC) value >0.80, demonstrating their potential as a biomarker of AIS. Among them, six metabolites are firstly reported to distinguish between AIS patients and healthy individuals. Conclusion: These 12 metabolites can be further researched as potential diagnostic biomarkers of AIS.