Preliminary findings from the Dynamics of the Immune Responses to Repeat Influenza Vaccination Exposures (DRIVE I) Study: a Randomized Controlled Trial.
Benjamin John CowlingSook-San WongJefferson J S SantosLisa TouyonJordan OrtNaiqing YeNatalie K M KwokFaith HoSamuel M S ChengDennis K M IpMalik PeirisRichard J WebbyPatrick C WilsonSophie A ValkenburgJohn S TsangNancy H L LeungScott E HensleySarah CobeyPublished in: medRxiv : the preprint server for health sciences (2024)
In the first two years, repeat vaccinees and first-time vaccinees had similar post-vaccination geometric mean titers to all four vaccine strains, indicative of similar levels of clinical protection. The vaccine strains of A(H1N1) and A(H3N2) were updated in year 2, providing an opportunity to explore antigenic distances between those strains in humans in subsequent years.