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Two Bioactive Compounds, Uniformides A and B, Isolated from a Culture of Nocardia uniformis IFM0856 T in the Presence of Animal Cells.

Yasumasa HaraKeiichiro WatanabeAkiko TakayaTeruhisa ManomeTakashi YaguchiMasami Ishibashi
Published in: Organic letters (2022)
Two new peptides named uniformides A and B ( 1 and 2 , respectively) were isolated from the cultured extracts of Nocardia uniformis IFM0856 T in the presence of mouse macrophage-like cell line J774.1, in modified Czapek-Dox medium. These compounds were not produced in a culture containing only N. uniformis but in one that also included J774.1. Compounds 1 and 2 showed high cytotoxicity against J774.1 and suppressed the production of nitric oxide, IL-6, and IL-1β by inhibiting the NF-κB pathway.
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