Protective effects of verbenalin and (+)-eudesmin against 6-hydroxydopamine-induced oxidative/nitrosative stress in SH-SY5Y cells.

Ayşe Nur DemiryürekÖzge GöktürkAhmet SaracalogluSeniz DemiryürekDemiryürek Tuncay Abdullah

Published in: Molecular biology reports (2022)

These results indicated that verbenalin and (+)-eudesmin exert potent cytoprotective activities against cytotoxicity triggered by 6-OHDA in neuroblastoma cells. This is the first report demonstrating that verbenalin may act as a peroxynitrite scavenger.

Keyphrases

induced apoptosis
cell cycle arrest
cell death
signaling pathway
high glucose
anti inflammatory
stress induced